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Wednesday, July 31, 2013

The Naked Mole Rat's Anti-Cancer Secret

They've evolved a high molecular mass form of hyaluronan.  This is hypothesized to prevent cells from forming tumors.  In humans, hyaluronan and related molecules are thought to aid cancer metastasis:



Abbreviations:

HA - hyaluronic acid, a synonym for hyaluronan
HAS - hyaluronic acid synthase, makes HA
HAR - hyaluronic acid receptor
HAase/HYAL - hyaluronidase, enzyme that degrades the extracellular matrix

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